Assay Detail
Functional
CHEMBL4838823
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Antimalarial activity against artemisinin-resistant Plasmodium falciparum Cam3.II^C580Y expressing K13 mutant assessed as reduction in parasite growth measured after 72 hrs by Monash assay based fluorescence analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and development of 2-aminobenzimidazoles as potent antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.91 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4853337 | — | — | 1 | 7.20 |
| CHEMBL4867274 | — | — | 1 | 7.09 |
| CHEMBL4866549 | — | — | 1 | 6.94 |
| CHEMBL4850193 | — | — | 1 | 6.86 |
| CHEMBL4849926 | — | — | 1 | 6.78 |
| CHEMBL3289817 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4853337 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4867274 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4866549 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL4850193 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4849926 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL3289817 | — | IC50 | = | 264.0 | nM | 6.58 |