Assay Detail
Binding
CHEMBL4838840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Influenza A virus (A/California/04/2009 (H1N1)) Neuraminidase H274Y mutant using MUNANA as substrate preincubated for 5 to 15 mins followed by substrate addition and measured after 30 mins by fluorescence spectrophotometric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus (A/California/04/2009(H1N1)) |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Neuraminidase (CHEMBL3559643) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/USSR/90/1977 H1N1) |
Publication
Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.55 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860142 | — | — | 1 | 6.93 |
| CHEMBL4867418 | — | — | 1 | 6.88 |
| CHEMBL4863905 | — | — | 1 | 6.83 |
| CHEMBL4873884 | — | — | 1 | 6.42 |
| CHEMBL4797391 | — | — | 1 | 6.18 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | -1.0 | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860142 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL4867418 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4863905 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL4873884 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL4797391 | — | IC50 | = | 667.0 | nM | 6.18 |
| CHEMBL674 | OSELTAMIVIR CARBOXYLATE | IC50 | = | 828.0 | nM | 6.08 |