Assay Detail
Binding
CHEMBL4839006
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Inhibition of recombinant FAK (unknown origin) by radiometric kinase assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Thieno[3,2-<i>d</i>]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.29 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4851157 | — | — | 1 | 8.15 |
| CHEMBL4846921 | — | — | 1 | 8.15 |
| CHEMBL4873104 | — | — | 1 | 8.10 |
| CHEMBL4846553 | — | — | 1 | 8.00 |
| CHEMBL4874196 | — | — | 1 | 7.96 |
| CHEMBL4877875 | — | — | 1 | 7.92 |
| CHEMBL4854620 | — | — | 1 | 7.92 |
| CHEMBL4853724 | — | — | 1 | 7.92 |
| CHEMBL4857298 | — | — | 1 | 7.89 |
| CHEMBL4846093 | — | — | 1 | 7.82 |
| CHEMBL4872520 | — | — | 1 | 7.80 |
| CHEMBL4878656 | — | — | 1 | 7.75 |
| CHEMBL4849384 | — | — | 1 | 7.75 |
| CHEMBL4861088 | — | — | 1 | 7.75 |
| CHEMBL4861397 | — | — | 1 | 7.68 |
| CHEMBL4862392 | — | — | 1 | 7.68 |
| CHEMBL4858365 | — | — | 1 | 7.58 |
| CHEMBL4860735 | — | — | 1 | 7.54 |
| CHEMBL4871809 | — | — | 1 | 7.52 |
| CHEMBL4867151 | — | — | 1 | 7.51 |
| CHEMBL4867910 | — | — | 1 | 7.48 |
| CHEMBL4877120 | — | — | 1 | 7.46 |
| CHEMBL4861021 | — | — | 1 | 7.44 |
| CHEMBL4876873 | — | — | 1 | 7.31 |
| CHEMBL4876098 | — | — | 1 | 7.27 |
| CHEMBL4879263 | — | — | 1 | 7.26 |
| CHEMBL4873271 | — | — | 1 | 7.23 |
| CHEMBL4874015 | — | — | 1 | 7.17 |
| CHEMBL4869934 | — | — | 1 | 7.11 |
| CHEMBL4874892 | — | — | 1 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4851157 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4846921 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4873104 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4846553 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4874196 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4877875 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4854620 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4853724 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4857298 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4846093 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4872520 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4849384 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4861088 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4878656 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4862392 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4861397 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4858365 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4860735 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4871809 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4867151 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4867910 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4877120 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4861021 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4876873 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4876098 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4879263 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4873271 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4874015 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4869934 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4874892 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4879025 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4878892 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL205098 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4867693 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL4849868 | — | IC50 | = | 361.0 | nM | 6.44 |
| CHEMBL4850705 | — | IC50 | = | 668.0 | nM | 6.17 |
| CHEMBL4878530 | — | IC50 | = | 717.0 | nM | 6.14 |
| CHEMBL4878440 | — | IC50 | = | 1645.0 | nM | 5.78 |
| CHEMBL4868316 | — | IC50 | = | 2355.0 | nM | 5.63 |
| CHEMBL4858147 | — | IC50 | = | 4032.0 | nM | 5.39 |
| CHEMBL4855302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3137331 | DEFACTINIB | IC50 | < | 0.5 | nM | - |