Assay Detail
Functional
CHEMBL4839255
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Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Irbesartan Derivatives as BLT2 Agonists by Virtual Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.57 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | 4.0 | 1 | 8.22 |
| CHEMBL4872989 | — | — | 1 | 7.82 |
| CHEMBL4856425 | — | — | 1 | 7.60 |
| CHEMBL4877651 | — | — | 1 | 7.50 |
| CHEMBL116170 | — | — | 1 | 6.81 |
| CHEMBL439968 | — | — | 1 | 6.72 |
| CHEMBL4859498 | — | — | 1 | 6.41 |
| CHEMBL4868159 | — | — | 1 | 6.00 |
| CHEMBL444060 | — | — | 1 | 5.11 |
| CHEMBL115771 | — | — | 1 | 5.06 |
| CHEMBL4854916 | — | — | 1 | 5.00 |
| CHEMBL423325 | — | — | 1 | - |
| CHEMBL4850970 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1513 | IRBESARTAN | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4872989 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4856425 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4877651 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL116170 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL439968 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4859498 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4868159 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL444060 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL115771 | — | IC50 | = | 8650.0 | nM | 5.06 |
| CHEMBL4854916 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL423325 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4850970 | — | IC50 | - | — | - |