Assay Detail
Functional
CHEMBL4839279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-sensitive synchronized Plasmodium falciparum NF54 late trophozoite stage assessed as reduction in parasite survival incubated for 72 hrs under hypoxic condition by parasite lactate dehydrogenase based NBT microplate reader assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies Reveal New Astemizole Analogues Active against <i>Plasmodium falciparum</i> In Vitro.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 6.43 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.40 |
| CHEMBL4870498 | — | — | 1 | 7.60 |
| CHEMBL4878008 | — | — | 1 | 7.46 |
| CHEMBL4845682 | — | — | 1 | 7.37 |
| CHEMBL4873570 | — | — | 1 | 7.17 |
| CHEMBL4867115 | — | — | 1 | 7.15 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 7.07 |
| CHEMBL4856116 | — | — | 1 | 6.97 |
| CHEMBL4870175 | — | — | 1 | 6.81 |
| CHEMBL4848003 | — | — | 1 | 6.81 |
| CHEMBL4864536 | — | — | 1 | 6.79 |
| CHEMBL4854035 | — | — | 1 | 6.73 |
| CHEMBL4853871 | — | — | 1 | 6.70 |
| CHEMBL4852576 | — | — | 1 | 6.69 |
| CHEMBL4870928 | — | — | 1 | 6.62 |
| CHEMBL4855930 | — | — | 1 | 6.60 |
| CHEMBL4864996 | — | — | 1 | 6.60 |
| CHEMBL4863264 | — | — | 1 | 6.58 |
| CHEMBL4858358 | — | — | 1 | 6.53 |
| CHEMBL4865822 | — | — | 1 | 6.50 |
| CHEMBL4849566 | — | — | 1 | 6.50 |
| CHEMBL4868855 | — | — | 1 | 6.48 |
| CHEMBL4856394 | — | — | 1 | 6.45 |
| CHEMBL4847937 | — | — | 1 | 6.31 |
| CHEMBL4870154 | — | — | 1 | 6.25 |
| CHEMBL4868736 | — | — | 1 | 6.24 |
| CHEMBL4874966 | — | — | 1 | 6.23 |
| CHEMBL4857256 | — | — | 1 | 6.21 |
| CHEMBL4871227 | — | — | 1 | 6.19 |
| CHEMBL4869885 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4870498 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4878008 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4845682 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4873570 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4867115 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL296419 | ASTEMIZOLE | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4856116 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4870175 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL4848003 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL4864536 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4854035 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4853871 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL4852576 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL4870928 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL4855930 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL4864996 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL4863264 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL4858358 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL4865822 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL4849566 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL4868855 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4856394 | — | IC50 | = | 357.0 | nM | 6.45 |
| CHEMBL4847937 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL4870154 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL4868736 | — | IC50 | = | 579.0 | nM | 6.24 |
| CHEMBL4874966 | — | IC50 | = | 591.0 | nM | 6.23 |
| CHEMBL4857256 | — | IC50 | = | 624.0 | nM | 6.21 |
| CHEMBL4871227 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4869885 | — | IC50 | = | 691.0 | nM | 6.16 |
| CHEMBL4862830 | — | IC50 | = | 706.0 | nM | 6.15 |
| CHEMBL4848243 | — | IC50 | = | 755.0 | nM | 6.12 |
| CHEMBL4869345 | — | IC50 | = | 759.0 | nM | 6.12 |
| CHEMBL4875062 | — | IC50 | = | 1248.0 | nM | 5.90 |
| CHEMBL4852936 | — | IC50 | = | 1386.0 | nM | 5.86 |
| CHEMBL4850317 | — | IC50 | = | 1542.0 | nM | 5.81 |
| CHEMBL4849683 | — | IC50 | = | 1613.0 | nM | 5.79 |
| CHEMBL4876459 | — | IC50 | = | 1677.0 | nM | 5.78 |
| CHEMBL4856501 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL4871162 | — | IC50 | = | 1912.0 | nM | 5.72 |
| CHEMBL1504080 | — | IC50 | = | 2890.0 | nM | 5.54 |
| CHEMBL4848964 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL4846897 | — | IC50 | = | 4152.0 | nM | 5.38 |
| CHEMBL4858498 | — | IC50 | = | 5080.0 | nM | 5.29 |
| CHEMBL4859285 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL4856218 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL4846385 | — | IC50 | > | 6000.0 | nM | - |
| CHEMBL4860373 | — | IC50 | > | 6000.0 | nM | - |