Assay Detail
Binding
CHEMBL4839370
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Inhibition of PI3K in human MCF7 cells assessed as reduction in phosphorylation of AKT at Ser473 residue incubated for 30 mins by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.97 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860779 | — | — | 1 | 6.76 |
| CHEMBL4875626 | — | — | 1 | 6.36 |
| CHEMBL4871998 | — | — | 1 | 6.29 |
| CHEMBL4850640 | — | — | 1 | 6.01 |
| CHEMBL4851439 | — | — | 1 | 5.98 |
| CHEMBL4860129 | — | — | 1 | 5.98 |
| CHEMBL4849035 | — | — | 1 | 5.83 |
| CHEMBL4873263 | — | — | 1 | 5.42 |
| CHEMBL4867528 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860779 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4875626 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL4871998 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL4850640 | — | IC50 | = | 985.0 | nM | 6.01 |
| CHEMBL4851439 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4860129 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4849035 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4873263 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL4867528 | — | IC50 | = | 7530.0 | nM | 5.12 |