Assay Detail
Binding
CHEMBL4839675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX12 (CHEMBL3687) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.87 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869861 | — | — | 1 | 7.30 |
| CHEMBL3113165 | VLX-1005 | 2.0 | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869861 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3113165 | VLX-1005 | IC50 | = | 360.0 | nM | 6.44 |