Assay Detail
Binding
CHEMBL4839718
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.53 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4853196 | — | — | 1 | 6.54 |
| CHEMBL4863873 | — | — | 1 | 6.11 |
| CHEMBL4869437 | — | — | 1 | 5.96 |
| CHEMBL4848550 | — | — | 1 | 5.36 |
| CHEMBL4876663 | — | — | 1 | 5.16 |
| CHEMBL4867297 | — | — | 1 | 5.02 |
| CHEMBL4846092 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4853196 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4863873 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4869437 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4848550 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4876663 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4867297 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4846092 | — | EC50 | = | 26000.0 | nM | 4.58 |