Assay Detail
Functional
CHEMBL4840216
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Antimalarial activity against chloroquine resistant Plasmodium falciparum W2 infected in human red blood cells assessed as reduction in parasite growth measured after 72 hrs by parasite lactate dehydrogenase assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Potent 3-Br-isoxazoline-Based Antimalarial and Antileishmanial Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.89 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4854616 | — | — | 1 | 7.24 |
| CHEMBL3329248 | — | — | 1 | 6.58 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.39 |
| CHEMBL4562798 | — | — | 1 | 6.32 |
| CHEMBL4869051 | — | — | 1 | 5.46 |
| CHEMBL4873920 | — | — | 1 | 4.82 |
| CHEMBL4869503 | — | — | 1 | 4.57 |
| CHEMBL4868589 | — | — | 1 | 4.49 |
| CHEMBL4867348 | — | — | 1 | 4.49 |
| CHEMBL4862588 | — | — | 1 | 4.47 |
| CHEMBL4865981 | — | — | 1 | 4.41 |
| CHEMBL4871929 | — | — | 1 | 4.40 |
| CHEMBL4878292 | — | — | 1 | 4.40 |
| CHEMBL4869428 | — | — | 1 | 4.39 |
| CHEMBL4860772 | — | — | 1 | 4.38 |
| CHEMBL4845868 | — | — | 1 | 4.37 |
| CHEMBL4868878 | — | — | 1 | 4.37 |
| CHEMBL4863846 | — | — | 1 | 4.34 |
| CHEMBL4865319 | — | — | 1 | 4.34 |
| CHEMBL4871534 | — | — | 1 | 4.32 |
| CHEMBL4852746 | — | — | 1 | 4.19 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4854616 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3329248 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL4562798 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4869051 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4873920 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4869503 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4868589 | — | IC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL4867348 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL4862588 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4865981 | — | IC50 | = | 39300.0 | nM | 4.41 |
| CHEMBL4871929 | — | IC50 | = | 39700.0 | nM | 4.40 |
| CHEMBL4878292 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL4869428 | — | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL4860772 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL4845868 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4868878 | — | IC50 | = | 42500.0 | nM | 4.37 |
| CHEMBL4863846 | — | IC50 | = | 45300.0 | nM | 4.34 |
| CHEMBL4865319 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4871534 | — | IC50 | = | 48100.0 | nM | 4.32 |
| CHEMBL4852746 | — | IC50 | = | 64800.0 | nM | 4.19 |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | - | — | - |