Assay Detail
Functional
CHEMBL4840290
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Anti-HIV activity against HIV1 3B infected in human PBMC assessed as inhibition of viral infection measured after 11 days by ELISA method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-Trifluoromethylthiazole-5-carboxamides: Analogues of a Stilbene-Based Anti-HIV Agent that Impact HIV mRNA Processing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.70 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | 8.26 |
| CHEMBL4845743 | — | — | 1 | 6.13 |
| CHEMBL4874932 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL885 | EMTRICITABINE | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4845743 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4874932 | — | EC50 | = | 1930.0 | nM | 5.71 |