Assay Detail
Functional
CHEMBL4840468
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.13 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856835 | — | — | 1 | 4.19 |
| CHEMBL4849505 | — | — | 1 | 4.14 |
| CHEMBL4866306 | — | — | 1 | 4.05 |
| CHEMBL4862017 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856835 | — | IC50 | = | 64180.0 | nM | 4.19 |
| CHEMBL4849505 | — | IC50 | = | 72290.0 | nM | 4.14 |
| CHEMBL4866306 | — | IC50 | = | 88530.0 | nM | 4.05 |
| CHEMBL4862017 | — | IC50 | > | 100000.0 | nM | - |