Assay Detail
Functional
CHEMBL4840894
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-MDR activity in human MCF7-DOX cells assessed as reversal of cell resistance to doxorubicin by measuring doxorubicin IC50 at 30 uM measured after 48 hrs by MTT assay (Rvb = 60.9 +/- 0.65 uM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7-DOX |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Limonoids with Diverse Oxidation Patterns of C-12 Indicating a Complete Ring C-<i>seco</i> Biogenetic Pathway from <i>Munronia unifoliolata</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.10 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2229171 | DIACETYLVILASININ | — | 1 | 5.48 |
| CHEMBL4865693 | — | — | 1 | 4.94 |
| CHEMBL3581414 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2229171 | DIACETYLVILASININ | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL4865693 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL3581414 | — | IC50 | = | 13500.0 | nM | 4.87 |