Assay Detail
ADMET
CHEMBL4840951
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Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition measured after 72 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MCF-10A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.36 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2312139 | — | — | 1 | 4.68 |
| CHEMBL4846565 | — | — | 1 | 4.04 |
| CHEMBL3188386 | WNT-974 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2312139 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4846565 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL3188386 | WNT-974 | IC50 | > | 100000.0 | nM | - |