Assay Detail
Functional
CHEMBL4841188
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Cytotoxicity against human CEM-VLB cells assessed as reduction in cell viability incubated for 72 hrs by PrestoBlue reagent based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CEM-VLB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Oral Anticancer 1,2-Bis(hydroxymethyl)benzo[<i>g</i>]pyrrolo[2,1-<i>a</i>]phthalazine Hybrids That Inhibit Angiogenesis and Induce DNA Cross-Links.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.64 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4879183 | — | — | 1 | 7.52 |
| CHEMBL4872568 | — | — | 1 | 7.00 |
| CHEMBL4871641 | — | — | 1 | 7.00 |
| CHEMBL4867439 | — | — | 1 | 7.00 |
| CHEMBL4874361 | — | — | 1 | 6.85 |
| CHEMBL4856371 | — | — | 1 | 6.60 |
| CHEMBL4873164 | — | — | 1 | 6.50 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.41 |
| CHEMBL4854342 | — | — | 1 | 6.25 |
| CHEMBL4869983 | — | — | 1 | 6.00 |
| CHEMBL4851847 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4879183 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4872568 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4871641 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4867439 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4874361 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4856371 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4873164 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 392.48 | nM | 6.41 |
| CHEMBL4854342 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4869983 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL4851847 | — | IC50 | = | 1200.0 | nM | 5.92 |