Assay Detail
Binding
CHEMBL4841255
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Inhibition of CDK2 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.13 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4872952 | — | — | 1 | 7.46 |
| CHEMBL4863726 | — | — | 1 | 7.28 |
| CHEMBL4860265 | — | — | 1 | 7.25 |
| CHEMBL4856767 | — | — | 1 | 7.17 |
| CHEMBL4855785 | — | — | 1 | 6.83 |
| CHEMBL4876497 | — | — | 1 | 6.79 |
| CHEMBL4857229 | — | — | 1 | - |
| CHEMBL4786559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4872952 | — | IC50 | = | 34.48 | nM | 7.46 |
| CHEMBL4863726 | — | IC50 | = | 52.86 | nM | 7.28 |
| CHEMBL4860265 | — | IC50 | = | 56.13 | nM | 7.25 |
| CHEMBL4856767 | — | IC50 | = | 67.44 | nM | 7.17 |
| CHEMBL4855785 | — | IC50 | = | 146.85 | nM | 6.83 |
| CHEMBL4876497 | — | IC50 | = | 163.95 | nM | 6.79 |
| CHEMBL4857229 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4786559 | — | IC50 | > | 1000.0 | nM | - |