Assay Detail
Functional
CHEMBL4841298
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Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell proliferation measured after 3 to 7 days by MTS assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.06 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4876497 | — | — | 1 | 8.27 |
| CHEMBL4786559 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4876497 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4786559 | — | IC50 | = | 14.0 | nM | 7.85 |