Assay Detail
Binding
CHEMBL4841342
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Inhibition of RSK4 (unknown origin) incubated for 40 mins in presence of ATP and lipid substrate by Kinase-Glo plus luminescence assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.65 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847762 | — | — | 1 | 8.02 |
| CHEMBL573107 | — | — | 1 | 7.94 |
| CHEMBL4846725 | — | — | 1 | 7.92 |
| CHEMBL4847469 | — | — | 1 | 7.92 |
| CHEMBL4870231 | — | — | 1 | 7.82 |
| CHEMBL4870807 | — | — | 1 | 7.81 |
| CHEMBL4846978 | — | — | 1 | 7.75 |
| CHEMBL4845942 | — | — | 1 | 7.60 |
| CHEMBL4872665 | — | — | 1 | 7.54 |
| CHEMBL4852908 | — | — | 1 | 7.48 |
| CHEMBL4850890 | — | — | 1 | 7.26 |
| CHEMBL4856762 | — | — | 1 | 7.08 |
| CHEMBL4869608 | — | — | 1 | 6.93 |
| CHEMBL4852557 | — | — | 1 | 6.52 |
| CHEMBL4850184 | — | — | 1 | 6.40 |
| CHEMBL4874868 | — | — | 1 | 6.39 |
| CHEMBL4865220 | — | — | 1 | 5.67 |
| CHEMBL4846647 | — | — | 1 | 5.45 |
| CHEMBL4866663 | — | — | 1 | 5.33 |
| CHEMBL4868071 | — | — | 1 | 5.13 |
| CHEMBL4871187 | — | — | 1 | 5.01 |
| CHEMBL4848180 | — | — | 1 | 4.98 |
| CHEMBL4854622 | — | — | 1 | 4.86 |
| CHEMBL4849875 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847762 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL573107 | — | IC50 | = | 11.5 | nM | 7.94 |
| CHEMBL4846725 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4847469 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4870231 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4870807 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL4846978 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4845942 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4872665 | — | IC50 | = | 28.5 | nM | 7.54 |
| CHEMBL4852908 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4850890 | — | IC50 | = | 54.9 | nM | 7.26 |
| CHEMBL4856762 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4869608 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL4852557 | — | IC50 | = | 300.5 | nM | 6.52 |
| CHEMBL4850184 | — | IC50 | = | 395.0 | nM | 6.40 |
| CHEMBL4874868 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4865220 | — | IC50 | = | 2118.0 | nM | 5.67 |
| CHEMBL4846647 | — | IC50 | = | 3588.0 | nM | 5.45 |
| CHEMBL4866663 | — | IC50 | = | 4725.0 | nM | 5.33 |
| CHEMBL4868071 | — | IC50 | = | 7343.5 | nM | 5.13 |
| CHEMBL4871187 | — | IC50 | = | 9735.0 | nM | 5.01 |
| CHEMBL4848180 | — | IC50 | = | 10567.0 | nM | 4.98 |
| CHEMBL4854622 | — | IC50 | = | 13781.0 | nM | 4.86 |
| CHEMBL4849875 | — | IC50 | = | 17627.0 | nM | 4.75 |