Assay Detail
Functional
CHEMBL4841360
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Antiproliferative activity against human TE-10 cells assessed as inhibition of cell proliferation measured up to 48 hrs by CCK-8 assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TE-10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery, Optimization, and Structure-Activity Relationship Study of Novel and Potent RSK4 Inhibitors as Promising Agents for the Treatment of Esophageal Squamous Cell Carcinoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.79 | 6.24 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847762 | — | — | 2 | 6.24 |
| CHEMBL573107 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847762 | — | IC50 | = | 569.7 | nM | 6.24 |
| CHEMBL573107 | — | IC50 | = | 4553.0 | nM | 5.34 |
| CHEMBL4847762 | — | Inhibition | - | % | - |