Assay Detail
Functional
CHEMBL4841688
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human REC-1 cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Rec1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 1-Amino-1<i>H</i>-imidazole-5-carboxamide Derivatives as Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.68 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3707348 | ACALABRUTINIB | 4.0 | 1 | 7.89 |
| CHEMBL4864983 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3707348 | ACALABRUTINIB | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4864983 | — | IC50 | = | 35.0 | nM | 7.46 |