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Assay Detail

CHEMBL4841804

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of B-Raf (unknown origin)
ChEMBL ↗
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf.
Patterson JR, Graves AP, Stoy P, Cheung M, Desai TA, Fries H, Gatto GJ, Holt DA, Shewchuk L, Totoritis R, Wang L, Kallander LS.
J Med Chem (2021) 64 : 15651 -15670
PubMed 34699203 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 53 6.43 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3613195 — — 1 8.22
CHEMBL4857556 — — 1 7.80
CHEMBL4845883 — — 1 7.50
CHEMBL1336 SORAFENIB 4.0 1 7.42
CHEMBL4856992 — — 1 7.20
CHEMBL4861519 — — 1 7.20
CHEMBL4863203 — — 1 7.20
CHEMBL4870768 — — 1 7.00
CHEMBL4859380 — — 1 6.80
CHEMBL4870490 — — 1 6.70
CHEMBL4867760 — — 1 6.70
CHEMBL4094739 — — 1 6.60
CHEMBL4852364 — — 1 6.50
CHEMBL4869054 — — 1 6.40
CHEMBL4850780 — — 1 6.40
CHEMBL4868251 — — 1 6.40
CHEMBL4874491 — — 1 6.30
CHEMBL4863580 — — 1 6.30
CHEMBL4864463 — — 1 6.30
CHEMBL4868391 — — 1 6.30
CHEMBL4875220 — — 1 6.20
CHEMBL1233853 — — 1 6.20
CHEMBL4877505 — — 1 6.20
CHEMBL4859309 — — 1 6.10
CHEMBL4873406 — — 1 6.10
CHEMBL4847826 — — 1 6.00
CHEMBL4856623 — — 1 6.00
CHEMBL3815093 — — 1 6.00
CHEMBL4850251 — — 1 6.00
CHEMBL4850964 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3613195 — IC50 = 6.0 nM 8.22
CHEMBL4857556 — IC50 = 16.0 nM 7.80
CHEMBL4845883 — IC50 = 32.0 nM 7.50
CHEMBL1336 SORAFENIB IC50 = 38.0 nM 7.42
CHEMBL4856992 — IC50 = 63.0 nM 7.20
CHEMBL4861519 — IC50 = 63.0 nM 7.20
CHEMBL4863203 — IC50 = 63.0 nM 7.20
CHEMBL4870768 — IC50 = 100.0 nM 7.00
CHEMBL4859380 — IC50 = 160.0 nM 6.80
CHEMBL4870490 — IC50 = 200.0 nM 6.70
CHEMBL4867760 — IC50 = 200.0 nM 6.70
CHEMBL4094739 — IC50 = 250.0 nM 6.60
CHEMBL4852364 — IC50 = 320.0 nM 6.50
CHEMBL4850780 — IC50 = 400.0 nM 6.40
CHEMBL4869054 — IC50 = 400.0 nM 6.40
CHEMBL4868251 — IC50 = 400.0 nM 6.40
CHEMBL4874491 — IC50 = 500.0 nM 6.30
CHEMBL4863580 — IC50 = 500.0 nM 6.30
CHEMBL4864463 — IC50 = 500.0 nM 6.30
CHEMBL4868391 — IC50 = 500.0 nM 6.30
CHEMBL4875220 — IC50 = 630.0 nM 6.20
CHEMBL1233853 — IC50 = 630.0 nM 6.20
CHEMBL4877505 — IC50 = 630.0 nM 6.20
CHEMBL4859309 — IC50 = 800.0 nM 6.10
CHEMBL4873406 — IC50 = 800.0 nM 6.10
CHEMBL4847826 — IC50 = 1000.0 nM 6.00
CHEMBL4871527 — IC50 = 1000.0 nM 6.00
CHEMBL4850964 — IC50 = 1000.0 nM 6.00
CHEMBL3815093 — IC50 = 1000.0 nM 6.00
CHEMBL4856623 — IC50 = 1000.0 nM 6.00
CHEMBL4850251 — IC50 = 1000.0 nM 6.00
CHEMBL4865829 — IC50 = 1260.0 nM 5.90
CHEMBL4857725 — IC50 = 1260.0 nM 5.90
CHEMBL4872243 — IC50 = 1260.0 nM 5.90
CHEMBL4864978 — IC50 = 1260.0 nM 5.90
CHEMBL4854957 — IC50 = 1600.0 nM 5.80
CHEMBL4066096 — IC50 = 1600.0 nM 5.80
CHEMBL4849349 — IC50 = 1600.0 nM 5.80
CHEMBL4868757 — IC50 = 2000.0 nM 5.70
CHEMBL4856147 — IC50 > 2000.0 nM -
CHEMBL4876578 — IC50 > 2000.0 nM -
CHEMBL4873277 — IC50 > 2000.0 nM -
CHEMBL1992306 — IC50 - — -
CHEMBL4859818 — IC50 > 2000.0 nM -
CHEMBL4870044 — IC50 > 2000.0 nM -
CHEMBL4869303 — IC50 > 2000.0 nM -
CHEMBL4865373 — IC50 > 2000.0 nM -
CHEMBL4856606 — IC50 > 2000.0 nM -
CHEMBL4867552 — IC50 > 2000.0 nM -
CHEMBL4875166 — IC50 > 2000.0 nM -