Assay Detail
Functional
CHEMBL4841965
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Antiviral activity against HBV infected in human HepG2-hNTCP cells assessed as reduction in HBV DNA incubated for day 1 followed by compound washout and fresh compound addition on following day and day 3, 6 and 10 measured on day 14 post infection by qPCR analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 8.69 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4875146 | — | — | 1 | 9.70 |
| CHEMBL4859319 | — | — | 1 | 9.57 |
| CHEMBL4878556 | — | — | 1 | 9.22 |
| CHEMBL4869422 | — | — | 1 | 9.15 |
| CHEMBL4854971 | — | — | 1 | 8.92 |
| CHEMBL4865455 | — | — | 1 | 8.89 |
| CHEMBL4868959 | — | — | 1 | 8.85 |
| CHEMBL4855770 | — | — | 1 | 8.85 |
| CHEMBL4863664 | — | — | 1 | 8.80 |
| CHEMBL4877554 | — | — | 1 | 8.55 |
| CHEMBL4877971 | — | — | 1 | 8.49 |
| CHEMBL4849286 | — | — | 1 | 8.47 |
| CHEMBL4864042 | — | — | 1 | 8.44 |
| CHEMBL4849197 | — | — | 1 | 8.40 |
| CHEMBL4859604 | — | — | 1 | 8.38 |
| CHEMBL4873511 | — | — | 1 | 8.36 |
| CHEMBL2364637 | TENOFOVIR ALAFENAMIDE FUMARATE | 4.0 | 1 | 8.28 |
| CHEMBL4855762 | — | — | 1 | 8.14 |
| CHEMBL4877392 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4875146 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4859319 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL4878556 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4869422 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4854971 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4865455 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4868959 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4855770 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4863664 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4877554 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4877971 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4849286 | — | EC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4864042 | — | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4849197 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4859604 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4873511 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL2364637 | TENOFOVIR ALAFENAMIDE FUMARATE | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4855762 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4877392 | — | EC50 | = | 19.0 | nM | 7.72 |