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Assay Detail

CHEMBL4842101

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-LSD from 5HT2C receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method
14
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293T
Subcellular Membrane
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2C (CHEMBL225)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

2-Phenylcyclopropylmethylamine Derivatives as Dopamine D<sub>2</sub> Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation.
Yan W, Fan L, Yu J, Liu R, Wang H, Tan L, Wang S, Cheng J.
J Med Chem (2021) 64 : 17239 -17258
PubMed 34797051 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 6.63 7.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1112 ARIPIPRAZOLE 4.0 2 7.02
CHEMBL4862890 2 6.91
CHEMBL2028019 CARIPRAZINE 4.0 2 6.70
CHEMBL4863832 2 6.52
CHEMBL4862770 2 6.43
CHEMBL4875081 2 6.22
CHEMBL54 HALOPERIDOL 4.0 1 -
CHEMBL441618 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1112 ARIPIPRAZOLE Ki = 95.4 nM 7.02
CHEMBL1112 ARIPIPRAZOLE Ki = 95.5 nM 7.02
CHEMBL4862890 Ki = 122.3 nM 6.91
CHEMBL4862890 Ki = 123.03 nM 6.91
CHEMBL2028019 CARIPRAZINE Ki = 198.2 nM 6.70
CHEMBL2028019 CARIPRAZINE Ki = 199.53 nM 6.70
CHEMBL4863832 Ki = 304.6 nM 6.52
CHEMBL4863832 Ki = 302.0 nM 6.52
CHEMBL4862770 Ki = 373.0 nM 6.43
CHEMBL4862770 Ki = 371.54 nM 6.43
CHEMBL4875081 Ki = 604.0 nM 6.22
CHEMBL4875081 Ki = 602.56 nM 6.22
CHEMBL54 HALOPERIDOL Ki - -
CHEMBL441618 Ki - -