Assay Detail
Binding
CHEMBL4842189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli recombinant his-tagged DHDPS using (S)-aspartate-semialdehyde as a substrate preincubated for 12 mins followed by substrate addition by UV-Vis spectrophotometer based coupled DHDPS-DHDPR assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 4.14 | 4.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857694 | — | — | 1 | 4.41 |
| CHEMBL4870896 | — | — | 1 | 4.34 |
| CHEMBL2263549 | — | — | 1 | 4.33 |
| CHEMBL4878800 | — | — | 1 | 4.23 |
| CHEMBL4855538 | — | — | 1 | 4.18 |
| CHEMBL4854833 | — | — | 1 | 4.17 |
| CHEMBL4860391 | — | — | 1 | 4.17 |
| CHEMBL4852051 | — | — | 1 | 4.16 |
| CHEMBL4876751 | — | — | 1 | 4.15 |
| CHEMBL1645382 | — | — | 1 | 4.15 |
| CHEMBL85496 | — | — | 1 | 4.15 |
| CHEMBL4851437 | — | — | 1 | 4.14 |
| CHEMBL4871255 | — | — | 1 | 4.14 |
| CHEMBL4862909 | — | — | 1 | 4.13 |
| CHEMBL142385 | — | — | 1 | 4.12 |
| CHEMBL4856954 | — | — | 1 | 4.10 |
| CHEMBL4858261 | — | — | 1 | 4.10 |
| CHEMBL4852655 | — | — | 1 | 4.10 |
| CHEMBL2259676 | — | — | 1 | 4.10 |
| CHEMBL4876769 | — | — | 1 | 4.08 |
| CHEMBL4876904 | — | — | 1 | 4.06 |
| CHEMBL4861787 | — | — | 1 | 4.05 |
| CHEMBL4864672 | — | — | 1 | 4.05 |
| CHEMBL4857652 | — | — | 1 | 4.04 |
| CHEMBL4861407 | — | — | 1 | 4.03 |
| CHEMBL4852496 | — | — | 1 | 4.01 |
| CHEMBL4857868 | — | — | 1 | 4.01 |
| CHEMBL4866997 | — | — | 1 | - |
| CHEMBL4861910 | — | — | 1 | - |
| CHEMBL4871089 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857694 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4870896 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL2263549 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL4878800 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4855538 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL4854833 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL4860391 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL4852051 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL4876751 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL85496 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL1645382 | — | IC50 | = | 71000.0 | nM | 4.15 |
| CHEMBL4851437 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4871255 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4862909 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL142385 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL4856954 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2259676 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4852655 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4858261 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL4876769 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL4876904 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL4861787 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL4864672 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL4857652 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL4861407 | — | IC50 | = | 94000.0 | nM | 4.03 |
| CHEMBL4857868 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL4852496 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL4858562 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL4873111 | — | IC50 | = | 108000.0 | nM | - |
| CHEMBL4851193 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL4864884 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4866144 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL4875881 | — | IC50 | = | 153000.0 | nM | - |
| CHEMBL2263550 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1540184 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL4863908 | — | IC50 | = | 316000.0 | nM | - |
| CHEMBL486917 | — | IC50 | = | 103000.0 | nM | - |
| CHEMBL4858699 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL1645383 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL4876179 | — | IC50 | = | 222000.0 | nM | - |
| CHEMBL1631303 | — | IC50 | = | 540000.0 | nM | - |
| CHEMBL38043 | — | IC50 | = | 124000.0 | nM | - |
| CHEMBL566474 | — | IC50 | = | 156000.0 | nM | - |
| CHEMBL1956800 | — | IC50 | = | 323000.0 | nM | - |
| CHEMBL224521 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL4851977 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL4871089 | — | IC50 | = | 121000.0 | nM | - |
| CHEMBL4861910 | — | IC50 | = | 125000.0 | nM | - |
| CHEMBL4866997 | — | IC50 | > | 250000.0 | nM | - |