Assay Detail
Binding
CHEMBL4842273
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Inhibition of JNK1 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluorescence assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the c-Jun N-Terminal Kinase Inhibitor <b>CC-90001</b>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.89 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856984 | — | — | 1 | 9.00 |
| CHEMBL4849353 | — | — | 1 | 9.00 |
| CHEMBL4853125 | — | — | 1 | 8.70 |
| CHEMBL4864618 | — | — | 1 | 8.70 |
| CHEMBL4878370 | — | — | 1 | 8.70 |
| CHEMBL4853525 | — | — | 1 | 8.52 |
| CHEMBL4847078 | — | — | 1 | 8.52 |
| CHEMBL4862107 | — | — | 1 | 8.52 |
| CHEMBL4845965 | — | — | 1 | 8.52 |
| CHEMBL4875131 | — | — | 1 | 8.30 |
| CHEMBL4878046 | — | — | 1 | 8.22 |
| CHEMBL4877655 | — | — | 1 | 8.00 |
| CHEMBL4877389 | — | — | 1 | 8.00 |
| CHEMBL4862452 | — | — | 1 | 7.96 |
| CHEMBL4847106 | CC-90001 | 2.0 | 1 | 7.96 |
| CHEMBL4872066 | — | — | 1 | 7.96 |
| CHEMBL4874549 | — | — | 1 | 7.89 |
| CHEMBL4861847 | — | — | 1 | 7.85 |
| CHEMBL4852708 | — | — | 1 | 7.77 |
| CHEMBL4857485 | — | — | 1 | 7.75 |
| CHEMBL4861369 | — | — | 1 | 7.72 |
| CHEMBL4866929 | — | — | 1 | 7.72 |
| CHEMBL4877560 | — | — | 1 | 7.70 |
| CHEMBL4851639 | — | — | 1 | 7.57 |
| CHEMBL4848290 | — | — | 1 | 7.46 |
| CHEMBL4848449 | — | — | 1 | 7.43 |
| CHEMBL4874419 | — | — | 1 | 7.30 |
| CHEMBL4848796 | — | — | 1 | 7.28 |
| CHEMBL4858138 | — | — | 1 | 7.26 |
| CHEMBL4852680 | — | — | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856984 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4849353 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4853125 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4864618 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4878370 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4853525 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4847078 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4862107 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4845965 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4875131 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4878046 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4877655 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4877389 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4872066 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4847106 | CC-90001 | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4862452 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4874549 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4861847 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4852708 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4857485 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4861369 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4866929 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4877560 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4851639 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4848290 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4848449 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4874419 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4848796 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4858138 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4852680 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1950289 | TANZISERTIB | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL4875491 | — | IC50 | = | 6000.0 | nM | 5.22 |