Assay Detail
Functional
CHEMBL4842292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at 5HT2A receptor (unknown origin) expressed in HEK293 cells by FLIPR calcium flux assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Psychedelic Renaissance: Addressing Potential Adverse Effects in a Therapeutic Setting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.01 | 8.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 8.75 |
| CHEMBL4877402 | — | — | 1 | 8.26 |
| CHEMBL65547 | PSILOCIN | 2.0 | 1 | 8.19 |
| CHEMBL4873240 | — | — | 1 | 7.69 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | 2.0 | 1 | 7.65 |
| CHEMBL4871007 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7257 | MEBUFOTENIN | EC50 | = | 1.76 | nM | 8.75 |
| CHEMBL4877402 | — | EC50 | = | 5.54 | nM | 8.26 |
| CHEMBL65547 | PSILOCIN | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4873240 | — | EC50 | = | 20.6 | nM | 7.69 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | EC50 | = | 22.2 | nM | 7.65 |
| CHEMBL4871007 | — | EC50 | = | 30.5 | nM | 7.52 |