Assay Detail
Binding
CHEMBL4842297
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-17A in human HDF cells assessed as IL-6 release incubated for 5 hrs by TR-FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HDF |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Difluorocyclohexyl Derivatives as IL-17 Modulators for Treating Inflammatory and Autoimmune Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.69 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870813 | — | — | 1 | 9.00 |
| CHEMBL4860574 | — | — | 1 | 8.70 |
| CHEMBL4865978 | — | — | 1 | 8.70 |
| CHEMBL4872143 | — | — | 1 | 8.70 |
| CHEMBL4850368 | — | — | 1 | 8.52 |
| CHEMBL4851738 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870813 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4860574 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4865978 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4872143 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4850368 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4851738 | — | IC50 | = | 3.0 | nM | 8.52 |