Assay Detail
Binding
CHEMBL4842434
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-competitive inhibition of human LDHA assessed as reduction in lactate production using pyruvate as substrate in presence of NADH by Lineweaver-Burk plot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cannabichromene and Δ<sup>9</sup>-Tetrahydrocannabinolic Acid Identified as Lactate Dehydrogenase-A Inhibitors by <i>in Silico</i> and <i>in Vitro</i> Screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.93 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL465718 | DELTA9-TETRAHYDROCANNABINOLIC ACID A | — | 1 | 5.19 |
| CHEMBL422704 | CANNABICHROMENE | — | 1 | 5.07 |
| CHEMBL465 | DRONABINOL | 4.0 | 1 | 4.85 |
| CHEMBL190461 | CANNABIDIOL | 4.0 | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL465718 | DELTA9-TETRAHYDROCANNABINOLIC ACID A | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL422704 | CANNABICHROMENE | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL465 | DRONABINOL | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL190461 | CANNABIDIOL | Ki | = | 24000.0 | nM | 4.62 |