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Assay Detail

CHEMBL4842449

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Tick-borne encephalitis virus infected in pig PEK cells assessed as reduction in virus plaque formation preincubated with virus for 1 hr followed by cell infection and measured after 1 hr by crystal violet staining based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Tick-borne encephalitis virus
Confidence 1 — Organism
Curated By Autocuration

Target

Tick-borne encephalitis virus (CHEMBL4296604)
Type ORGANISM
Organism Tick-borne encephalitis virus

Publication

Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses.
Kozlovskaya LI, Volok VP, Shtro AA, Nikolaeva YV, Chistov AA, Matyugina ES, Belyaev ES, Jegorov AV, Snoeck R, Korshun VA, Andrei G, Osolodkin DI, Ishmukhametov AA, Aralov AV.
Eur J Med Chem (2021) 220 : 113467 -113467
PubMed 33894564 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 4.93 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4876888 1 5.60
CHEMBL4853972 1 5.55
CHEMBL4858629 1 5.40
CHEMBL4852062 1 5.28
CHEMBL4867320 1 5.27
CHEMBL4865141 1 4.82
CHEMBL4875977 1 4.80
CHEMBL4870983 1 4.80
CHEMBL4876346 1 4.66
CHEMBL4857025 1 4.63
CHEMBL4872020 1 4.44
CHEMBL4859942 1 4.40
CHEMBL4873641 1 4.40
CHEMBL4846008 1 -
CHEMBL4878050 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4876888 EC50 = 2530.0 nM 5.60
CHEMBL4853972 EC50 = 2800.0 nM 5.55
CHEMBL4858629 EC50 = 4000.0 nM 5.40
CHEMBL4852062 EC50 = 5300.0 nM 5.28
CHEMBL4867320 EC50 = 5400.0 nM 5.27
CHEMBL4865141 EC50 = 15000.0 nM 4.82
CHEMBL4875977 EC50 = 16000.0 nM 4.80
CHEMBL4870983 EC50 = 16000.0 nM 4.80
CHEMBL4876346 EC50 = 22000.0 nM 4.66
CHEMBL4857025 EC50 = 23600.0 nM 4.63
CHEMBL4872020 EC50 = 36000.0 nM 4.44
CHEMBL4859942 EC50 = 40000.0 nM 4.40
CHEMBL4873641 EC50 = 40000.0 nM 4.40
CHEMBL4846008 EC50 > 50000.0 nM -
CHEMBL4878050 EC50 > 50000.0 nM -