Assay Detail
Functional
CHEMBL4842450
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Antiviral activity against Powassan virus infected in pig PEK cells assessed as reduction in virus plaque formation preincubated with virus for 1 hr followed by cell infection and measured after 1 hr by crystal violet staining based assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Powassan virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phenoxazine nucleoside derivatives with a multiple activity against RNA and DNA viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.21 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4867320 | — | — | 1 | 6.35 |
| CHEMBL4853972 | — | — | 1 | 5.82 |
| CHEMBL4876888 | — | — | 1 | 5.62 |
| CHEMBL4859942 | — | — | 1 | 5.36 |
| CHEMBL4852062 | — | — | 1 | 5.11 |
| CHEMBL4870983 | — | — | 1 | 5.10 |
| CHEMBL4876346 | — | — | 1 | 4.88 |
| CHEMBL4875977 | — | — | 1 | 4.87 |
| CHEMBL4858629 | — | — | 1 | 4.82 |
| CHEMBL4872020 | — | — | 1 | 4.68 |
| CHEMBL4865141 | — | — | 1 | 4.66 |
| CHEMBL4873641 | — | — | 1 | - |
| CHEMBL4846008 | — | — | 1 | - |
| CHEMBL4878050 | — | — | 1 | - |
| CHEMBL4857025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4867320 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4853972 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4876888 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4859942 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4852062 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4870983 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4876346 | — | EC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4875977 | — | EC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL4858629 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4872020 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4865141 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4873641 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4846008 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4878050 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4857025 | — | EC50 | > | 50000.0 | nM | - |