Assay Detail
ADMET
CHEMBL4842475
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Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by WST-1 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.38 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4857754 | — | — | 1 | 5.89 |
| CHEMBL4869807 | — | — | 1 | 5.42 |
| CHEMBL4856045 | — | — | 1 | 4.84 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | - |
| CHEMBL4859406 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4857754 | — | EC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4869807 | — | EC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL4856045 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL307261 | ARTENIMOL | EC50 | > | 25000.0 | nM | - |
| CHEMBL4859406 | — | EC50 | > | 30000.0 | nM | - |