Assay Detail
Functional
CHEMBL4842479
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.38 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4868442 | — | — | 1 | 9.02 |
| CHEMBL4850572 | — | — | 1 | 8.98 |
| CHEMBL4871791 | — | — | 1 | 8.69 |
| CHEMBL4857754 | — | — | 1 | 8.59 |
| CHEMBL4856045 | — | — | 1 | 8.57 |
| CHEMBL4869807 | — | — | 1 | 8.48 |
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 8.30 |
| CHEMBL4845812 | — | — | 1 | 8.21 |
| CHEMBL4857262 | — | — | 1 | 7.96 |
| CHEMBL4853187 | — | — | 1 | 7.78 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.57 |
| CHEMBL4859406 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4868442 | — | EC50 | = | 0.95 | nM | 9.02 |
| CHEMBL4850572 | — | EC50 | = | 1.04 | nM | 8.98 |
| CHEMBL4871791 | — | EC50 | = | 2.03 | nM | 8.69 |
| CHEMBL4857754 | — | EC50 | = | 2.57 | nM | 8.59 |
| CHEMBL4856045 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4869807 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL307261 | ARTENIMOL | EC50 | = | 4.97 | nM | 8.30 |
| CHEMBL4845812 | — | EC50 | = | 6.12 | nM | 8.21 |
| CHEMBL4857262 | — | EC50 | = | 10.9 | nM | 7.96 |
| CHEMBL4853187 | — | EC50 | = | 16.73 | nM | 7.78 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4859406 | — | EC50 | > | 100000.0 | nM | - |