Assay Detail
Functional
CHEMBL4842480
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Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum 7G8 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 8.91 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869807 | — | — | 1 | 9.64 |
| CHEMBL4856045 | — | — | 1 | 9.33 |
| CHEMBL4857754 | — | — | 1 | 8.92 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869807 | — | EC50 | = | 0.23 | nM | 9.64 |
| CHEMBL4856045 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4857754 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL269671 | ARTEMISININ | EC50 | = | 18.0 | nM | 7.75 |