Assay Detail
Binding
CHEMBL4842900
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.92 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 7.24 |
| CHEMBL4876454 | — | — | 1 | 6.57 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.85 |
| CHEMBL4066043 | — | — | 1 | 5.54 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 5.52 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4876454 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL356769 | TUBACIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4066043 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 16400.0 | nM | 4.79 |