Assay Detail
Binding
CHEMBL4842907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC8 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 3, 4-disubstituted-imidazolidine-2, 5-dione derivatives as HDAC6 selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.95 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 7.00 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 6.07 |
| CHEMBL2179618 | NEXTURASTAT A | — | 1 | 6.02 |
| CHEMBL356769 | TUBACIN | — | 1 | 5.90 |
| CHEMBL4066043 | — | — | 1 | 5.55 |
| CHEMBL4876454 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 854.0 | nM | 6.07 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL356769 | TUBACIN | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4066043 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4876454 | — | IC50 | = | 6851.0 | nM | 5.16 |