Assay Detail
Binding
CHEMBL4843170
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Inhibition of full length Dengue virus 2 NS5 RNA dependent RNA polymerase incubated for 10 mins by picogreen staining based fluorescent analysis (Rvb= 0.32+/-0.05 uM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.36 | 4.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848338 | — | — | 1 | 4.36 |
| CHEMBL4845724 | — | — | 1 | - |
| CHEMBL4847429 | — | — | 1 | - |
| CHEMBL4873306 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848338 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL4845724 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4847429 | — | IC50 | = | 153200.0 | nM | - |
| CHEMBL4873306 | — | IC50 | > | 100000.0 | nM | - |