Assay Detail
Binding
CHEMBL4843234
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in mouse Panc02 cells assessed as reduction in NFK level incubated for 48 hrs by RFMS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Panc02 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.11 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4858888 | — | — | 1 | 9.00 |
| CHEMBL4855340 | — | — | 1 | 8.80 |
| CHEMBL4856710 | — | — | 1 | 8.70 |
| CHEMBL4861332 | — | — | 1 | 7.85 |
| CHEMBL4853212 | — | — | 1 | 7.64 |
| CHEMBL4870435 | — | — | 1 | 7.64 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4858888 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4855340 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4856710 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4861332 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4853212 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4870435 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 74.0 | nM | 7.13 |