Assay Detail
Binding
CHEMBL4843236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged IDO1 (Ala2 to Gly403 residues) expressed in Escherichia coli using tryptophan as substrate preincubated for 10 mins followed by substrate addition and measured after 1 hr by RFMS assay
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.41 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 8.46 |
| CHEMBL3989951 | NAVOXIMOD | 2.0 | 2 | 7.85 |
| CHEMBL4853212 | — | — | 1 | 7.62 |
| CHEMBL4870435 | — | — | 1 | 7.17 |
| CHEMBL4086143 | PF-06840003 | 1.0 | 1 | 6.67 |
| CHEMBL4872488 | — | — | 1 | - |
| CHEMBL4868286 | — | — | 1 | - |
| CHEMBL4878270 | — | — | 1 | - |
| CHEMBL4856573 | — | — | 1 | - |
| CHEMBL4868833 | — | — | 1 | - |
| CHEMBL4852532 | — | — | 1 | - |
| CHEMBL4872522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3989951 | NAVOXIMOD | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4853212 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4870435 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3989951 | NAVOXIMOD | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4086143 | PF-06840003 | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL4872488 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4868286 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL4878270 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4856573 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL4868833 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL4852532 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4872522 | — | IC50 | > | 50000.0 | nM | - |