Assay Detail
Binding
CHEMBL4843237
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Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assay
63
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 7.94 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873747 | — | — | 1 | 9.28 |
| CHEMBL4856710 | — | — | 1 | 9.22 |
| CHEMBL4858888 | — | — | 1 | 9.16 |
| CHEMBL4849690 | — | — | 1 | 9.04 |
| CHEMBL4875089 | — | — | 1 | 9.00 |
| CHEMBL4868112 | — | — | 1 | 8.85 |
| CHEMBL4872522 | — | — | 1 | 8.80 |
| CHEMBL4861332 | — | — | 1 | 8.77 |
| CHEMBL4859064 | — | — | 2 | 8.66 |
| CHEMBL4866976 | — | — | 1 | 8.59 |
| CHEMBL4866113 | — | — | 1 | 8.59 |
| CHEMBL4863359 | — | — | 1 | 8.47 |
| CHEMBL4846356 | — | — | 1 | 8.44 |
| CHEMBL4869547 | — | — | 1 | 8.41 |
| CHEMBL4856417 | — | — | 1 | 8.40 |
| CHEMBL4873928 | — | — | 1 | 8.38 |
| CHEMBL4853672 | — | — | 1 | 8.36 |
| CHEMBL4858219 | — | — | 1 | 8.34 |
| CHEMBL4849414 | — | — | 1 | 8.28 |
| CHEMBL4866916 | — | — | 1 | 8.28 |
| CHEMBL4854742 | — | — | 1 | 8.21 |
| CHEMBL4846874 | — | — | 1 | 8.21 |
| CHEMBL4852566 | — | — | 1 | 8.21 |
| CHEMBL4878766 | — | — | 1 | 8.20 |
| CHEMBL4853036 | — | — | 1 | 8.16 |
| CHEMBL4873803 | — | — | 1 | 8.15 |
| CHEMBL4872039 | — | — | 1 | 8.15 |
| CHEMBL4848111 | — | — | 1 | 8.08 |
| CHEMBL4871068 | — | — | 1 | 8.08 |
| CHEMBL4845961 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873747 | — | IC50 | = | 0.52 | nM | 9.28 |
| CHEMBL4856710 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4858888 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL4849690 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL4875089 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4868112 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4872522 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4861332 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4859064 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4866113 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4866976 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4859064 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4863359 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4846356 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4869547 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4856417 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4873928 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4853672 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4858219 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4866916 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4849414 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4852566 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4854742 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4846874 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4878766 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4853036 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4873803 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4872039 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4845961 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4848111 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4871068 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4848514 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL4872488 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL4864639 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4852532 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4862584 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4872803 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4873892 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4862755 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4861936 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4865079 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4878988 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4870664 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4853212 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4868833 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4865106 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4856573 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4877654 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4846783 | — | IC50 | = | 33.0 | nM | 7.48 |