Assay Detail
Binding
CHEMBL4843250
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by fluorescence polarization assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.61 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4849690 | — | — | 1 | 6.00 |
| CHEMBL4861332 | — | — | 1 | 5.62 |
| CHEMBL4858888 | — | — | 1 | 5.44 |
| CHEMBL4855340 | — | — | 1 | 5.38 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | - |
| CHEMBL4856710 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4849690 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4861332 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4858888 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4855340 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | > | 36000.0 | nM | - |
| CHEMBL4856710 | — | IC50 | > | 44000.0 | nM | - |