Assay Detail
Binding
CHEMBL4843263
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Inhibition of IDO1 in IFNgamma-stimulated mouse Panc02 cells incubated for 48 hrs by RFMS method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Panc02 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.58 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866113 | — | — | 1 | 7.64 |
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.13 |
| CHEMBL4846874 | — | — | 1 | 7.12 |
| CHEMBL4865079 | — | — | 1 | 6.97 |
| CHEMBL4848055 | — | — | 1 | 6.64 |
| CHEMBL4848111 | — | — | 1 | 6.24 |
| CHEMBL4873892 | — | — | 1 | 5.92 |
| CHEMBL4854742 | — | — | 1 | 5.89 |
| CHEMBL4853036 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866113 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4846874 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4865079 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL4848055 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4848111 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4873892 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4854742 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4853036 | — | IC50 | = | 2200.0 | nM | 5.66 |