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Assay Detail

CHEMBL4843290

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human ERG expressed in CHO by QPatch assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Hamilton MM, Mseeh F, McAfoos TJ, Leonard PG, Reyna NJ, Harris AL, Xu A, Han M, Soth MJ, Czako B, Theroff JP, Mandal PK, Burke JP, Virgin-Downey B, Petrocchi A, Pfaffinger D, Rogers NE, Parker CA, Yu SS, Jiang Y, Krapp S, Lammens A, Trevitt G, Tremblay MR, Mikule K, Wilcoxen K, Cross JB, Jones P, Marszalek JR, Lewis RT.
J Med Chem (2021) 64 : 11302 -11329
PubMed 34292726 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.26 6.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4846783 1 6.13
CHEMBL4853672 1 5.85
CHEMBL4870418 1 5.68
CHEMBL4848514 1 5.25
CHEMBL4859064 1 5.00
CHEMBL4861332 1 4.96
CHEMBL4845961 1 4.92
CHEMBL4871068 1 4.85
CHEMBL4864639 1 4.68
CHEMBL4863359 1 -
CHEMBL4849414 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4846783 IC50 = 740.0 nM 6.13
CHEMBL4853672 IC50 = 1400.0 nM 5.85
CHEMBL4870418 IC50 = 2100.0 nM 5.68
CHEMBL4848514 IC50 = 5600.0 nM 5.25
CHEMBL4859064 IC50 = 9900.0 nM 5.00
CHEMBL4861332 IC50 = 11000.0 nM 4.96
CHEMBL4845961 IC50 = 12000.0 nM 4.92
CHEMBL4871068 IC50 = 14000.0 nM 4.85
CHEMBL4864639 IC50 = 21000.0 nM 4.68
CHEMBL4863359 IC50 > 30000.0 nM -
CHEMBL4849414 IC50 > 30000.0 nM -