Assay Detail
Binding
CHEMBL4843307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in human whole blood stimulated with IFNgamma/LPS using L-tryptophan/kynurenine as substrate incubated for 15 mins followed by IFNgamma/LPS stimulation and incubated for 24 hrs by LC-MS analysis
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.43 | 7.85 |
| IC90 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4856710 | — | — | 2 | 7.85 |
| CHEMBL4855340 | — | — | 2 | 7.58 |
| CHEMBL4858888 | — | — | 2 | 7.34 |
| CHEMBL4861332 | — | — | 2 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4856710 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4855340 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4858888 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4861332 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL4861332 | — | IC90 | = | 1047.0 | nM | - |
| CHEMBL4858888 | — | IC90 | = | 411.0 | nM | - |
| CHEMBL4856710 | — | IC90 | = | 124.0 | nM | - |
| CHEMBL4855340 | — | IC90 | = | 260.0 | nM | - |