Assay Detail
Binding
CHEMBL4843396
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Inhibition of NS2B-NS3 intramolecular cleavage in Dengue virus 2 infected in LLC-MK2 cells assessed as inhibition of viral replication measured afer 48 hrs by ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Cell Type | LLC-MK2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Amidoxime prodrugs convert to potent cell-active multimodal inhibitors of the dengue virus protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.38 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1535689 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1535689 | — | EC50 | = | 4200.0 | nM | 5.38 |