Assay Detail
Functional
CHEMBL4843484
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of tanshinone IIA-based analogues: Potent inhibitors of microtubule formation and angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.60 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293458 | — | — | 1 | 5.89 |
| CHEMBL1976537 | — | — | 1 | 5.80 |
| CHEMBL4863620 | — | — | 1 | 5.62 |
| CHEMBL4848324 | — | — | 1 | 5.50 |
| CHEMBL4845904 | — | — | 1 | 5.45 |
| CHEMBL4856464 | — | — | 1 | 5.35 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | - |
| CHEMBL4858140 | — | — | 1 | - |
| CHEMBL4862954 | — | — | 1 | - |
| CHEMBL4873413 | — | — | 1 | - |
| CHEMBL4856123 | — | — | 1 | - |
| CHEMBL4873615 | — | — | 1 | - |
| CHEMBL4867477 | — | — | 1 | - |
| CHEMBL4861622 | — | — | 1 | - |
| CHEMBL4847389 | — | — | 1 | - |
| CHEMBL4869346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293458 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL1976537 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4863620 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL4848324 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4845904 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL4856464 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | > | 5000.0 | nM | - |
| CHEMBL4858140 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4862954 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4873413 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4856123 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4873615 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4867477 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4861622 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4847389 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4869346 | — | IC50 | > | 5000.0 | nM | - |