Assay Detail
Functional
CHEMBL4843485
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Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of tanshinone IIA-based analogues: Potent inhibitors of microtubule formation and angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.61 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848324 | — | — | 1 | 6.08 |
| CHEMBL1976537 | — | — | 1 | 5.72 |
| CHEMBL4863620 | — | — | 1 | 5.71 |
| CHEMBL4856464 | — | — | 1 | 5.64 |
| CHEMBL4873615 | — | — | 1 | 5.55 |
| CHEMBL4847389 | — | — | 1 | 5.54 |
| CHEMBL293458 | — | — | 1 | 5.45 |
| CHEMBL4862954 | — | — | 1 | 5.41 |
| CHEMBL4858140 | — | — | 1 | 5.40 |
| CHEMBL187266 | TANSHINONE IIA | — | 1 | - |
| CHEMBL4845904 | — | — | 1 | - |
| CHEMBL4873413 | — | — | 1 | - |
| CHEMBL4856123 | — | — | 1 | - |
| CHEMBL4867477 | — | — | 1 | - |
| CHEMBL4861622 | — | — | 1 | - |
| CHEMBL4869346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848324 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1976537 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL4863620 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4856464 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4873615 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4847389 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL293458 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL4862954 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL4858140 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL187266 | TANSHINONE IIA | IC50 | > | 5000.0 | nM | - |
| CHEMBL4845904 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4873413 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4856123 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4867477 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4861622 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL4869346 | — | IC50 | > | 5000.0 | nM | - |