Assay Detail
Binding
CHEMBL4843582
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Inhibition of SF-tagged FAP (unknown origin) expressed in Drosophila S2 cells using fluorogenic substrate by spectrometric analysis
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | S2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with α-ketoamide warheads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 8.80 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4877950 | — | — | 1 | 10.05 |
| CHEMBL4878759 | — | — | 1 | 9.89 |
| CHEMBL4864809 | — | — | 1 | 9.74 |
| CHEMBL4853661 | — | — | 1 | 9.72 |
| CHEMBL4850601 | — | — | 1 | 9.66 |
| CHEMBL4876026 | — | — | 1 | 9.51 |
| CHEMBL4868869 | — | — | 1 | 9.49 |
| CHEMBL4850484 | — | — | 1 | 9.48 |
| CHEMBL4867484 | — | — | 1 | 9.38 |
| CHEMBL4873985 | — | — | 1 | 9.38 |
| CHEMBL4864133 | — | — | 1 | 9.36 |
| CHEMBL4854865 | — | — | 1 | 9.30 |
| CHEMBL4871602 | — | — | 1 | 9.28 |
| CHEMBL4855449 | — | — | 1 | 9.24 |
| CHEMBL4859756 | — | — | 1 | 9.20 |
| CHEMBL4868282 | — | — | 1 | 9.20 |
| CHEMBL4863249 | — | — | 1 | 9.20 |
| CHEMBL4847764 | — | — | 1 | 9.19 |
| CHEMBL4851238 | — | — | 1 | 9.17 |
| CHEMBL4855309 | — | — | 1 | 9.11 |
| CHEMBL4846405 | — | — | 1 | 8.96 |
| CHEMBL4870279 | — | — | 1 | 8.96 |
| CHEMBL4870593 | — | — | 1 | 8.96 |
| CHEMBL4871573 | — | — | 1 | 8.82 |
| CHEMBL4861963 | — | — | 1 | 8.77 |
| CHEMBL4869146 | — | — | 1 | 8.74 |
| CHEMBL4864489 | — | — | 1 | 8.68 |
| CHEMBL3233842 | — | — | 1 | 8.64 |
| CHEMBL4872140 | — | — | 1 | 8.57 |
| CHEMBL4850470 | — | — | 1 | 8.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4877950 | — | IC50 | = | 0.089 | nM | 10.05 |
| CHEMBL4878759 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL4864809 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL4853661 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL4850601 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4876026 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL4868869 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4850484 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL4867484 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL4873985 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL4864133 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4854865 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4871602 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4855449 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL4863249 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4859756 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4868282 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL4847764 | — | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL4851238 | — | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL4855309 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL4846405 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4870279 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4870593 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4871573 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL4861963 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4869146 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4864489 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3233842 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4872140 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4850470 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4863606 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4870506 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4863090 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4875452 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4868792 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4874501 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4847560 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL2385281 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4870027 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4863794 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4873662 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4874657 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4874659 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4861885 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4857711 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4869363 | — | IC50 | = | 150.0 | nM | 6.82 |