Assay Detail
Functional
CHEMBL4843630
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In vivo inhibition of CETP in po dosed NFR-transgenic mouse measured at 60 mins
35
Total Activities
35
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.74 | 7.28 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873397 | — | — | 1 | 7.28 |
| CHEMBL3657473 | — | — | 1 | 7.27 |
| CHEMBL4864513 | — | — | 1 | 7.22 |
| CHEMBL4856674 | — | — | 1 | 7.07 |
| CHEMBL3657526 | — | — | 1 | 7.06 |
| CHEMBL4868133 | — | — | 1 | 7.05 |
| CHEMBL3657543 | — | — | 1 | 7.02 |
| CHEMBL3933320 | — | — | 1 | 7.01 |
| CHEMBL3657525 | — | — | 1 | 6.97 |
| CHEMBL3657524 | — | — | 1 | 6.92 |
| CHEMBL3657528 | — | — | 1 | 6.92 |
| CHEMBL3657529 | — | — | 1 | 6.91 |
| CHEMBL3657527 | — | — | 1 | 6.90 |
| CHEMBL4848777 | — | — | 1 | 6.89 |
| CHEMBL3657519 | — | — | 1 | 6.85 |
| CHEMBL4860512 | — | — | 1 | 6.81 |
| CHEMBL3657542 | — | — | 1 | 6.78 |
| CHEMBL4855997 | — | — | 1 | 6.74 |
| CHEMBL4857594 | — | — | 1 | 6.74 |
| CHEMBL3657536 | — | — | 1 | 6.73 |
| CHEMBL4860432 | — | — | 1 | 6.72 |
| CHEMBL4871292 | — | — | 1 | 6.64 |
| CHEMBL3657522 | — | — | 1 | 6.62 |
| CHEMBL4846038 | — | — | 1 | 6.61 |
| CHEMBL3657502 | — | — | 1 | 6.56 |
| CHEMBL3657501 | — | — | 1 | 6.37 |
| CHEMBL4865918 | — | — | 1 | 6.37 |
| CHEMBL3657540 | — | — | 1 | 6.25 |
| CHEMBL4856800 | — | — | 1 | 6.21 |
| CHEMBL3657505 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873397 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3657473 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL4864513 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4856674 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL3657526 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4868133 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3657543 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3933320 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL3657525 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL3657524 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3657528 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3657529 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL3657527 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4848777 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL3657519 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL4860512 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL3657542 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL4855997 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL4857594 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL3657536 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL4860432 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4871292 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL3657522 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL4846038 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL3657502 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4865918 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL3657501 | — | IC50 | = | 432.0 | nM | 6.37 |
| CHEMBL3657540 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4856800 | — | IC50 | = | 614.0 | nM | 6.21 |
| CHEMBL3657505 | — | IC50 | = | 714.0 | nM | 6.15 |
| CHEMBL3657535 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3657541 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL3657523 | — | IC50 | - | — | - | |
| CHEMBL4878757 | — | Activity | = | 0.9 | uM | - |
| CHEMBL4875851 | — | Activity | = | 1.4 | uM | - |