Assay Detail
ADMET
CHEMBL4843885
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Antiproliferative activity against human HEK293T cells assessed as reduction in cell viability incubated for 72 hrs by celltiter-glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship investigation for imidazopyrazole-3-carboxamide derivatives as novel selective inhibitors of Bruton's tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.41 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4869409 | — | — | 1 | 6.21 |
| CHEMBL4871192 | — | — | 1 | 6.05 |
| CHEMBL3647964 | — | — | 1 | 5.65 |
| CHEMBL4875332 | — | — | 1 | 5.38 |
| CHEMBL4878090 | — | — | 1 | 5.21 |
| CHEMBL4863078 | — | — | 1 | 4.95 |
| CHEMBL3936761 | ZANUBRUTINIB | 4.0 | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4869409 | — | IC50 | = | 620.7 | nM | 6.21 |
| CHEMBL4871192 | — | IC50 | = | 887.6 | nM | 6.05 |
| CHEMBL3647964 | — | IC50 | = | 2241.0 | nM | 5.65 |
| CHEMBL4875332 | — | IC50 | = | 4155.0 | nM | 5.38 |
| CHEMBL4878090 | — | IC50 | = | 6139.0 | nM | 5.21 |
| CHEMBL4863078 | — | IC50 | = | 11206.0 | nM | 4.95 |
| CHEMBL3936761 | ZANUBRUTINIB | IC50 | = | 39136.0 | nM | 4.41 |