Assay Detail
ADMET
CHEMBL4843957
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Inhibition of recombinant human HDAC1 using ZMAL as substrate incubated for 90 mins by fluorescence based micro plate assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.46 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.92 |
| CHEMBL4852163 | — | — | 1 | 6.44 |
| CHEMBL4870316 | — | — | 1 | 6.44 |
| CHEMBL4065863 | — | — | 1 | 5.47 |
| CHEMBL4853162 | — | — | 1 | 5.41 |
| CHEMBL3800394 | — | — | 1 | 5.20 |
| CHEMBL4870946 | — | — | 1 | 5.11 |
| CHEMBL4857763 | — | — | 1 | 4.96 |
| CHEMBL4870162 | — | — | 1 | 4.74 |
| CHEMBL4847326 | — | — | 1 | 4.73 |
| CHEMBL4867041 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4852163 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4870316 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4065863 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL4853162 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL3800394 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL4870946 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4857763 | — | IC50 | = | 10870.0 | nM | 4.96 |
| CHEMBL4870162 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL4847326 | — | IC50 | = | 18510.0 | nM | 4.73 |
| CHEMBL4867041 | — | IC50 | = | 21100.0 | nM | 4.68 |