Assay Detail
Binding
CHEMBL4844059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP-2 (unknown origin)
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.70 | 4.99 |
| Kd | 1 | 5.85 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3606021 | — | — | 1 | 5.85 |
| CHEMBL63354 | AMENTOFLAVONE | — | 1 | 4.99 |
| CHEMBL4303397 | — | — | 1 | 4.40 |
| CHEMBL4799284 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3606021 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL63354 | AMENTOFLAVONE | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4303397 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4799284 | — | IC50 | > | 1000.0 | nM | - |